Betson

Pharmacology of Betson Cream

Betamethasone Dipropionate is an anti-inflammatory, anti-pruritic, and vasoconstrictive topical corticosteroid. Lipocortin peptides are produced by betamethasone dipropionate. Phospholipase A2, an enzyme that induces the breakdown of leukocyte lysosomal membranes and the release of arachidonic acid, is inhibited by lipocortins. Endogenous inflammatory mediators such as prostaglandins, kinins, and histamine are formed and released less as a result of this action.

Betamethasone Dipropionate can be absorbed via normal intact skin, according to pharmacokinetics. Corticosteroids have variable degrees of binding to plasma proteins. Corticosteroids are mostly processed in the liver. The kidneys excrete lt.

Dosage & Administration of Betson Cream

Apply a thin film once or twice daily to cover completely the affected area. Patients with chronic psoriasis who have achieved at least a marked improvement in their psoriatic lesion (i.e., approximately 80% improvement) with Betamethasone Dipropionate may be maintained in remission with a pulse dosing regimen consisting of three consecutive applications of up to 3.5 g each of Betamethasone Dipropionate cream and ointment, twelve hours apart (e.g., morning, evening, following morning) to the previously affected areas once each week. For this purpose, Betamethasone Dipropionate cream and ointment should be applied to the lesion sites previously affected and treated. Patients on this pulse dose regimen who relapse should be reverted back to the conventional dosing regimen.

Contraindications

Hypersensitivity to Betamethasone Dipropionate, other corticosteroids, or any of the preparation's ingredients. Betamethasone Dipropionate, like other topical corticosteroids, is contraindicated in viral skin infections including vaccinia, varicella, and Herpes simplex, as well as TB, acne rosacea, fungal skin infections (moniliasis), perioral dermatitis, and ulcerative diseases.

Side Effects of Betson Cream

Paresthesia was recorded in 1.9 percent of patients in clinical trials, followed by rash, edema, and secondary infection, all of which occurred in less than 1% of patients. Other side effects of the medication included scorching and dry skin in 1.6 percent of patients and stinging in less than 1% of individuals.

Precautions & Warnings

Because of the danger of glaucoma and cataracts, Betamethasone Dipropionate should not be used in or near the eyes. If irritation or sensitization develops as a result of using Betamethasone Dipropionate, the medication should be stopped and appropriate therapy started. If an infection is present, an appropriate antifungal or antibacterial treatment should be given. Betamethasone Dipropionate should be stopped until the infection has been properly controlled if a favorable response does not occur quickly.

Because corticosteroids are known to be absorbed through the skin, the likelihood of systemic effects should be considered in patients receiving long-term or substantial topical treatment. Betamethasone Dipropionate should not be used under occlusive dressings since it will increase the corticosteroid's systemic absorption. The napkin can act as an occlusive dressing in infants, increasing absorption. When applying topical corticosteroids in patients with stasis dermatitis and other skin conditions with reduced circulation, appropriate precautions should be performed. The use of topical corticosteroid treatments for an extended period of time might cause striae or atrophy of the skin and subcutaneous tissue.

Therapeutic Class

Corticosteroid

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Generic of Betson Cream

Betamethasone Dipropionate