Nystat 500000 IU
Nystatin has fungicidal or fungistatic action against a wide range of pathogenic and nonpathogenic yeasts and fungi, including Candida albicans. Nystatin's antifungal action is mediated via binding to sterols in the fungal cell membrane. The membrane is no longer able to serve as a selective barrier as a result of binding, and potassium and other cellular components are lost. The gastric system absorbs it weakly.
Nystatin has fungicidal or fungistatic action against a wide range of pathogenic and nonpathogenic yeasts and fungi, including Candida albicans. Nystatin's antifungal action is mediated via binding to sterols in the fungal cell membrane. The membrane is no longer able to serve as a selective barrier as a result of binding, and potassium and other cellular components are lost. The gastric system absorbs it weakly.
Nystatin has fungicidal or fungistatic action against a wide range of pathogenic and nonpathogenic yeasts and fungi, including Candida albicans. Nystatin's antifungal action is mediated via binding to sterols in the fungal cell membrane. The membrane is no longer able to serve as a selective barrier as a result of binding, and potassium and other cellular components are lost. The gastric system absorbs it weakly.
Dosage & Administration
Children:
In intestinal and oral candidiasis (thrush): 1,00,000 units (1 ml) should be dropped into the mouth four times daily.The longer the suspension is kept in contact with the affected area in the mouth, before swallowing, the greater will be its effect.
For prophylaxis in the newborn: The suggested dose is 1,00,000 units (1 ml) once daily or as prescribed by the physician.
Adult:
For the treatment of intestinal or esophageal candidiasis: 5,00,000 units (5 ml) by mouth 3 or 4 times daily. The dose may be doubled, if required.
For prophylaxis of intestinal candidiasis in adults: 10,00,000 units (10 ml) daily.
For prophylaxis to suppress the over growth of Candida albicans in patients receiving broad spectrum antibiotic therapy: 10,00,000 units (10 ml) daily.
For the treatment of dental sores and oral infection: 1,00,000 units (1 ml) suspension should be dropped into the mouth four times daily.
Elderly: Older people with intestinal candidiasis who are unable to swallow tablets should be given 5,00,000 units (5 ml) suspension four times daily.
Side Effects
High dosages of Nystatin have occasionally been associated with nausea, vomiting, and diarrhoea. Its oral dosage has not been linked to any systemic effects or allergic reactions.
Pregnancy & Lactation
Pregnancy Category C: Mouth/Throat/PO/Topical
Pregnancy Category A: Vaginal
Precautions & Warnings
Because absorption from the gastrointestinal system is minimal, no additional precautions are necessary during pregnancy and breastfeeding.
Therapeutic Class
Drugs for subcutaneous and mycoses, Drugs used in Vaginal and Vulval condition
Storage Conditions
Keep cool and dry, and keep away from direct sunlight. Keep out of children's reach.