Metryl 400
Metronidazole could be a part of the imidazole lesson of antibacterial sedate and is classified remedially as an antiprotozoal specialist. The 5-nitro gather of Metronidazole is diminished by anaerobes metabolically. Thinks about have illustrated that the decreased shape of this medicate interatomic with DNA and gives the bactericidal activity of Metronidazole.
Metronidazole could be a part of the imidazole lesson of antibacterial sedate and is classified remedially as an antiprotozoal specialist. The 5-nitro gather of Metronidazole is diminished by anaerobes metabolically. Thinks about have illustrated that the decreased shape of this medicate interatomic with DNA and gives the bactericidal activity of Metronidazole.
Metronidazole could be a part of the imidazole lesson of antibacterial sedate and is classified remedially as an antiprotozoal specialist. The 5-nitro gather of Metronidazole is diminished by anaerobes metabolically. Thinks about have illustrated that the decreased shape of this medicate interatomic with DNA and gives the bactericidal activity of Metronidazole.
Dosage & Administration
Tablet and Suspension:
Trichomoniasis (Adults & Children over 10 yrs)-
200 mg tid or 400 mg bid for 7 days
800 mg in the morning and 1-2 gm at night for 2 days
2 gm as a single dose for 1 days
Trichomoniasis (Children)-
Children 7-10 yrs: 100 mg tid
Children 3-7 yrs: 100 mg bid
Children 1-3 yrs: 50 mg tid
Interaction
Disulfiram: Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently.
Alcohol: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterward because of the possibility of a disulfiram-like (Antabuse effect) reaction (flushing, vomiting, tachycardia). Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect and increased hemorrhagic risk caused by decreased hepatic catabolism. In the case of co-administration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with metronidazole.
Lithium: Plasma levels of lithium may be increased by metronidazole.
Cyclosporin: Serum cyclosporin and serum creatinine should be closely monitored when co-administration is necessary.
Phenytoin or phenobarbital: increased elimination of metronidazole resulting in reduced plasma levels.
5-Fluorouracil: Reduced clearance of 5-fluorouracil resulting in increased toxicity of 5-fluorouracil.
Busulfan: Plasma levels of busulfan may be increased by metronidazole, which may lead to severe busulfan toxicity.
Contraindications
Metronidazole is contraindicated in patients with a history of touchiness to Metronidazole or other Nitroimidazole subsidiaries.
Side Effect
US FDA Pregnancy Category of Metronidazole is B. There are, in any case, no satisfactory and well-controlled ponders in pregnant ladies. Since creature generation considers is not continuously prescient of human reaction, this medicate ought to be utilized amid pregnancy as it were in the event that clearly required. Metronidazole has been appeared to be excreted in the human drain. So, caution ought to be worked out when Metronidazole is managed by a nursing lady.
Pregnancy & Lactation
This should be prescribed in pregnancy and lactation only if absolutely required.
Precautions & Warnings
If for compelling reasons, metronidazole must be administered longer than the usually recommended duration, it is recommended that hematological tests, especially leucocyte count should be carried out regularly and that patients should be monitored for adverse reactions such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures).
Metronidazole should be administered with caution to patients with hepatic encephalopathy.
Patients should be warned that metronidazole may darken the urine.
Therapeutic Class
Amebicides, Anti-diarrheal Antiprotozoal.
Storage Conditions
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.