Administration & Dosage

Tablet and Suspension:

Trichomoniasis (Adults & Children over 10 yrs)-

• 200 mg tid or 400 mg bid for 7 days

• 800 mg in the morning and 1-2 gm at night for 2 days

• 2 gm as a single dose for 1 days

Trichomoniasis (Children)-

• Children 7-10 yrs: 100 mg tid

• Children 3-7 yrs: 100 mg bid

• Children 1-3 yrs: 50 mg tid

Intestinal amoebiasis (Adults & Children over 10 yrs)- 

• 800 mg tid for 5 days

Intestinal amoebiasis (Children)-

• Children 7-10 yrs: 400 mg tid

• Children 3-7 yrs: 200 mg qid

• Children 1-3 yrs: 200 mg tidExtra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-
  

  • 400-800 mg tid for 5-10 days

  Extra-intestinal & Asymptomatic amoebiasis (Children)-
  

  • Children 7-10 yrs: 200-400 mg tid

  • Children 3-7 yrs: 100-200 mg qid

  • Children 1-3 yrs: 100-200 mg tid

  Giardiasis (Adults & Children over 10 yrs)-
  

  • 2 gm once daily for 3 days

  Giardiasis (Children)-
  

  • Children 7-10 yrs: 1 gm once daily

  • Children 3-7 yrs: 600-800 mg once daily

  • Children 1-3 yrs: 500 mg once daily

  Acute ulcerative  gingivitis (Adults & Children over 10 yrs)-
  

  • 200 mg tid for 3 daysAcute ulcerative  gingivitis (Children)-
    

    • Children 7-10 yrs: 100 mg tid

    • Children 3-7 yrs: 100 mg bid

    • Children 1-3 yrs: 50 mg tid

    Acute dental infections (Adults & Children over 10 yrs)-
    

    • 200 mg tid for 3-7 days

    Bacterial Vaginosis (Adults & Children over 10 yrs)-
    

    • 400 mg bid for 7 days

    • 2 gm as a single dose for 1 days

    Leg ulcers and pressure sores (Adults & Children over 10 yrs)-
    

    • 400 mg tid for 7 days

    Anaerobic infections (Adults & Children over 10 yrs)-
    

    • 800 mg initially and then 400 mg tid for 7 days

    Anaerobic infections (Children)-
    

    • Children 1-10 yrs: 7.5 mg/kg tid

    Surgical prophylaxis (Adults & Children over 10 yrs)-
    

    • 400 mg tid started 24  hours before  surgery for 1 days

    Surgical prophylaxis (Children)-
    

    • Children 1-10 yrs: 7.5 mg/kg tid

      Vaginal Gel:

      The recommended dose is one applicator full of Metronidazole gel (approximately 5 grams containing approximately 37.5 mg of Metronidazole) intravaginally once or twice a day for 5 days. For once a day dosing, Metronidazole gel should be administered at bedtime.

      
      Suppository:

      Anaerobic Infections-
      

      • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours.

      • Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose.

      Surgical Prophylaxis-
      

      • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures.

      • Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures.

        IV Infusion:

        Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.
        

        • Adults and children over 12 years: Infuse 500 mg 8 hourly at a rate of 5 ml/minute and a maximum of 4 g should not be exceeded during a 24-hour period. Treatment for 7 days is sufficient for most patients, but treatment can be extended, especially for cases where reinfection is likely. For surgical prophylaxis, administration shortly before surgery should be followed by 8-hourly doses for the next 24 hours.

        • Children under 12 years: 7.5 mg/kg body weight/day every 8 hours at a rate of 5 ml/minute

Interaction

Disulfiram: Insane responses have been detailed in patients who were utilizing metronidazole and disulfiram concurrently. Alcohol: Alcoholic refreshments and drugs containing liquor ought to not be devoured amid treatment and for at slightest one day a while later since of the plausibility of a disulfiram-like (antabuse impact) response (flushing, heaving, tachycardia). Verbal anticoagulant treatment (warfarin sort): Potentiation of the anticoagulant impact and expanded hemorrhagic chance caused by diminished hepatic catabolism. In case of co-administration, prothrombin time ought to be more habitually checked and anticoagulant treatment balanced amid treatment with metronidazole. Lithium: Plasma levels of lithium may be expanded by metronidazole. Cyclosporin: Serum cyclosporin and serum creatinine ought to be closely checked when co-administration is necessary. Phenytoin or phenobarbital: expanded end of metronidazole coming about in decreased plasma levels.

Contraindications

Metronidazole is contraindicated in patients with a history of extreme touchiness to Metronidazole or other Nitroimidazole subordinates.

Side Effect

Metallic taste, sickness, spewing, the runs, laziness, rashes may be watched amid treatment.

Pregnancy & Lactation

US FDA Pregnancy Category of Metronidazole is B. There are, be that as it may, no satisfactory and well-controlled considers in pregnant ladies. Since creature propagation ponders are not continuously prescient of human reaction, this medicate ought to be utilized amid pregnancy as it were in the event that clearly required. Metronidazole have been appeared to be excreted in human drain. So, caution ought to be worked out when Metronidazole is managed to a nursing lady.

Precautions & Warnings

On the off chance that for compelling reasons, metronidazole must be managed longer than the more often than not suggested length, it is prescribed that hematological tests, particularly leucocyte check ought to be carried out frequently which patients ought to be observed for antagonistic responses such as fringe or central neuropathy (such as paresthesia, ataxia, tipsiness, convulsive seizures). Metronidazole ought to be managed with caution to patients with hepatic encephalopathy. Patients ought to be cautioned that metronidazole may obscure pee.

Therapeutic Class

Amoebicides, Anti-diarrhoeal Antiprotozoal

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.