Comprid XR 60
Gliclazide is a sulfonylurea of the second generation with hypoglycemic and possibly hematological effects. It reduces hepatic glucose production while stimulating insulin release from pancreatic -cells by promoting Ca+2 transport across the -cell membranes.
Gliclazide is a sulfonylurea of the second generation with hypoglycemic and possibly hematological effects. It reduces hepatic glucose production while stimulating insulin release from pancreatic -cells by promoting Ca+2 transport across the -cell membranes.
Gliclazide is a sulfonylurea of the second generation with hypoglycemic and possibly hematological effects. It reduces hepatic glucose production while stimulating insulin release from pancreatic -cells by promoting Ca+2 transport across the -cell membranes.
Dosage & Administration
The normal starting dose is 40 to 80 mg per day as a film coated tablet. When needed, the dosage can be raised to 320 mg daily in split doses. The medication should be taken before to a meal. Because Gliclazide is contraindicated in juvenile-onset diabetes, it is not used in children.
Gliclazide 30 mg is usually taken as 1 to 4 tablets per day, whereas Gliclazide 60 mg is used as 1 to 2 tablets per day as a single dose. It is suggested that the medication be taken first thing in the morning. It is best to take this medication before breakfast in order to avoid or reduce the risk of stomach problems.
Interaction
Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal medications, and Monoamine Oxidase inhibitors may enhance Gliclazide's hypoglycaemic effects. Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic medications, and Alcohol may decrease the hypoglycaemic impact of Gliclazide.
Contraindications
Gliclazide should not be used in the following situations:
Juvenile-onset (type-1) diabetes
Diabetes associated with Ketosis
Diabetic patients undergoing surgery, after severe injury or during infection
Patients having hypersensitivity for sulfonylurea group of drugs
Pregnant women and breast-feeding mother
Hepatic insufficiency
Side Effects
Hypoglycemia can occur in the presence of other diseases such as hepatic and renal dysfunction, starvation, and alcohol abuse. Headaches, gastrointestinal disturbances, nausea, dizziness, and skin responses such as rash, pruritus, and erythema are all possible side effects.
Pregnancy & Lactation
Pregnant women should avoid using gliclazide. It should not be used by a woman who is breastfeeding.
Precautions & Warnings
In individuals with hepatic impairment, gliclazide should be taken with caution. Gliclazide should not be taken if there is clear evidence of liver illness. Because gliclazide is thoroughly metabolized, it can be administered safely in individuals with renal failure. Gliclazide has a lower risk of hypoglycemia than the other sulfonylurea medications.
Therapeutic Class
Sulfonylureas
Storage Conditions
Store below 30°C and away from light in a cool, dry area.