Amodis 60 ml
Metronidazole is a member of the imidazole class of antibacterial drugs and is classified as an antiprotozoal drug in treatment. The 5 nitro group of metronidazole is reduced by the metabolism of anaerobic bacteria. Studies have shown that the reduced form of this drug interacts with DNA and produces the bactericidal effect of metronidazole.
Metronidazole is a member of the imidazole class of antibacterial drugs and is classified as an antiprotozoal drug in treatment. The 5 nitro group of metronidazole is reduced by the metabolism of anaerobic bacteria. Studies have shown that the reduced form of this drug interacts with DNA and produces the bactericidal effect of metronidazole.
Metronidazole is a member of the imidazole class of antibacterial drugs and is classified as an antiprotozoal drug in treatment. The 5 nitro group of metronidazole is reduced by the metabolism of anaerobic bacteria. Studies have shown that the reduced form of this drug interacts with DNA and produces the bactericidal effect of metronidazole.
Dosage & Administration of Amodis 60 ml
Tablets and suspensions:
trichomoniasis (adults and children over 10 years)
200 mg tid or 400 mg twice a day for 7 consecutive days
800 mg in the morning and 12 g at night for 2 days
2 g for 44 days Single dose
trichomoniasis (children)
children 7-10 years: 100 mg tid
children 3-7 years: 100 mg twice daily
children 1-3 years: 50 mg tid
intestinal amebiasis (adults and children 40 days 40 days, 45 mg daily , 45 times a day, 45 times every 4 months) children)
7-10-year-old children: 400 mg three times a day
3-7-year-old children: 200 mg four times a day
1-3-year-old children: 200 mg three times a day
parenteral and asymptomatic disease Ami Barbaric (adults and children) 44 days and 44 years Children over 44 years Amebiasis (children)
children 7-0 years: 200 400 mg tid
children 3-7 years: 100 200 mg qid
children 1-3 years: 100 200 mg tid
Giardiasis (Giardiasis for adults older than 10 days and children older than 44 years once daily with Giardi to over 44 years) Children over 344 years)
Children 7-10 years: 1 g per day
Children over 3-7 years: 600 800 mg
once a day Children 1-3 years: 500 mg once a day
acute ulcerative gingivitis (adults and children over 10 years) 200 mg 3 days
Acute ulcer 4-4 children 4-4 years 4-7 100 mg tid
3-7 years children: 100 mg twice a day
children 1-3 years: 50 mg three times a day
Acute dental infection (adults and children over 10 years)
200 mg three times a day for 37 consecutive days children
Bacterial Bacterial bacterial infections over 4 years 400 mg twice a day for 7 consecutive days
2 grams per day, single administration for 1 consecutive day
Leg ulcers and bedsores (adults and children over 10 years)
400 mg once daily for 7 consecutive days
Anaerobic infections (adults and children over 10 years) 804 The starting dose is mg, then 400 mg three times a day for 7 days Consecutive days
Anaerobic infection (children)
Children 1-10 years: 7.5 mg / kg three times a day
Surgical prevention (adults and children over 10 years)
400 mg three times a day
444 hours before surgery 444 hours per day
Surgical prevention (children)
Children aged 1-10 years: 7.5 mg / kg time
Interactions
Disulfiram: Patients who use metronidazole and disulfiram at the same time have reported psychotic reactions.
Alcohol: alcoholic beverages and alcohol-containing drugs should not be consumed during treatment and for at least one day after treatment, because disulfiram-like reactions (anti-abuse effects) (flushing, vomiting, tachycardia) may occur.
Oral anticoagulant therapy (warfarin type): The anticoagulant effect is enhanced, and the liver catabolism is reduced, leading to an increased risk of bleeding. In the case of co-administration, prothrombin time should be monitored more frequently and anticoagulant therapy should be adjusted during metronidazole treatment.
Lithium: Metronidazole can increase the content of lithium in the plasma.
Cyclosporine: When co-administration is required, serum cyclosporine and serum creatinine should be closely monitored.
Phenytoin or phenobarbital: increased elimination of metronidazole leads to decreased plasma levels.
5 Fluorouracil: The clearance rate of 5 Fluorouracil is reduced, which increases the toxicity of 5 Fluorouracil.
Busulfan: Metronidazole may increase the plasma concentration of busulfan, which can cause severe busulfan toxicity.
Contraindications
Patients who have a history of allergy to metronidazole or other nitroimidazole derivatives should not use metronidazole.
Side-Effects of Amodis 60 ml
Metallic smell, nausea, vomiting, diarrhea, drowsiness, and rash may occur during treatment.
Pregnancy & Lactation
The US FDA classifies pregnancy with metronidazole as B. However, there are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies do not always predict human response, the drug should be used during pregnancy only when clearly necessary. Metronidazole has been shown to be excreted in human milk. Therefore, caution should be exercised when administering metronidazole to lactating women.
Precautions & Warnings
If for convincing reasons, metronidazole must be administered for longer than the usual recommended duration, it is recommended to perform hematological tests, especially white blood cell counts, and monitor the patient for adverse reactions such as peripheral or central neuropathy (such as Such as feeling abnormal). , Ataxia, dizziness, seizures).
Metronidazole should be used with caution in patients with hepatic encephalopathy.
Patients should be informed that metronidazole may darken the urine.
Therapeutic Class
Amoebicides, Anti-diarrhoeal Antiprotozoal
Storage Conditions
Store below 30°C. Keep protected from light. Keep medicines out of the reach of children. Do not use later than the date of expiry.