Scabo 6
Ebastine is a long-acting and selective antagonist of the H1-histamine receptor. The inhibition of peripheral receptors remains constant after repeated administration. Following oral administration, ebastine is rapidly absorbed and undergoes extensive first-pass metabolism. Carebastine, a pharmacologically active acid metabolite, is almost completely converted from ebastine.
Ebastine is a long-acting and selective antagonist of the H1-histamine receptor. The inhibition of peripheral receptors remains constant after repeated administration. Following oral administration, ebastine is rapidly absorbed and undergoes extensive first-pass metabolism. Carebastine, a pharmacologically active acid metabolite, is almost completely converted from ebastine.
Ebastine is a long-acting and selective antagonist of the H1-histamine receptor. The inhibition of peripheral receptors remains constant after repeated administration. Following oral administration, ebastine is rapidly absorbed and undergoes extensive first-pass metabolism. Carebastine, a pharmacologically active acid metabolite, is almost completely converted from ebastine.
Dosage & Administration
Tablet:
Adults (over the age of 12): take 10 mg (one tablet) once a day.
5 mg (half tablet) once daily for children aged 6 to 12.
Adults (aged 12 and up) should take 10 mg (one tablet) once a day.
Children aged 6 to 12 should take 5 mg (half tablet) once a day.
Interaction
When ebastine is taken with either ketoconazole or erythromycin, the plasma level of ebastine rises, resulting in a longer QTc interval. Ebastine has no effect on theophylline, warfarin, cimetidine, diazepam, or alcohol pharmacokinetics. Alcohol and diazepam's sedative effects may be amplified.
Contraindications
Patients who have previously tested positive for Ebastine or any of its ingredients.
Side Effects
Headache, dry mouth, and drowsiness are the most common side effects. Abdominal pain, dyspepsia, nausea, and insomnia are less commonly reported side effects.
Pregnancy & Lactation
Antihistamines that don't make you sleepy
Precautions & Warnings
Up to 100 mg given once daily, no clinically significant signs or symptoms were observed. Ebastine does not have a specific antidote. Gastric lavage, vital function monitoring, including ECG, and symptomatic treatment should all be performed in the event of an accidental overdose.
Therapeutic Class
Antihistamines that don't make you sleepy
Storage Conditions
Store below 30°C, away from light, in a cool, dry place. Keep out of children's reach.